Stretch-Sensitivity of Stretch-Activated BKCa Channels in Post-Hatch Chick Ventricular Myocytes
نویسندگان
چکیده
منابع مشابه
Stretch activated ion channels in ventricular myocytes.
Patch-clamp recordings from ventricular myocytes of neonatal rats identified ionic channels that open in response to membrane stretch caused by negative pressures (1 to 6 cm Hg) in the electrode. The stretch response, consisting of markedly increased channel opening frequency, was maintained, with some variability, during long (greater than 40 seconds) stretch applications. The channels have a ...
متن کاملCharacterization of a newly found stretch-activated KCa,ATP channel in cultured chick ventricular myocytes.
With the use of the patch-clamp technique, five kinds of stretch-activated (SA) ion channels were identified on the basis of their single-channel conductances and ion selectivities in cultured chick ventricular myocytes. Because a high-conductance K+-selective channel predominated among these channels, we concentrated on characterizing its properties mostly using excised inside-out patches. Wit...
متن کاملAn ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytes.
AIMS To develop an ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytes consistent with experimental observations, that can be used to investigate the role of these currents in intact myocardium. METHODS AND RESULTS A non-specific cation-selective stretch-activated current I(ns), was incorporated into the Puglisi-Bers ionic model of epicardial, endoca...
متن کاملStretch-activated ion channels: what are they?
Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the channels to the external stress. In contrast, MSCs in nonspecialized cells appear activated by stress in the bilayer local to the channel--within about three...
متن کاملDynamic properties of stretch-activated K+ channels in adult rat atrial myocytes.
The effect of mechanical stress on the heart's electrical activity has been termed mechanoelectric feedback. The response to stretch depends upon the magnitude and the waveform of the stimulus, and upon the timing relative to the cardiac cycle. Stretch-activated ion channels (SACs) have been regarded as the most likely candidates for serving as the primary transducers of mechanical stress. We e...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.1824